Sam Curran, Pat Brown and Lewis Gregory were handed over his first T20 caps.
Saqib Mahmood and Matthew Parkinson are the other uncapped players.
England are likely to go unchanged after clinching the first game.
Jonny Bairstow (wk), Eoin Morgan (c), Tom Banton, Dawid Malan, James Vince, Sam Billings, Sam Curran, Tom Curran, Adil Rashid, Chris Jordan, Matthew Parkinson, Lewis Gregory, Joe Denly, Saqib Mahmood, Patrick Brown
New Zealand Team News
Kane Williamson is out due to hip injury, while Trent Boult rested for the first three T20i matches.
Tim Southee is leading the black caps.
Jimmy Neesham and Blair Tickner are yet to be used.
D Mitchell got some valuable runs off his bat and is likely to retain his place.
New Zealand might stick to their previous playine11 despite the defeat.
New Zealand Squad
Tim Seifert (wk), Tim Southee (c), Colin Munro, Martin Guptill, Ross Taylor, Colin de Grandhomme, James Neesham, Daryl Mitchell, Mitchell Santner, Ish Sodhi, Lockie Ferguson, Scott Kuggeleijn, Blair Tickner